Fildena 100 Tablets are a generic medicine that works well in treating male sexual dysfunction. It contains Sildenafil Citrate as its main active ingredient.
The pill enables the correct amount of blood flow to the penis through relaxing the muscles in the vessels. This improves the circulation of blood in this area, resulting in a firm erection.
Sildenafil citrate is a medication used to treat erectile dysfunction (ED). It works by inhibiting an enzyme called phosphodiesterase type 5 (PDE-5). PDE-5 is responsible for regulating blood flow in the penis. When PDE-5 is inhibited, cGMP levels increase and this increases the ability of blood to flow in the penis, which results in an erection.
The mechanism by which sildenafil works is complex and involves a number of chemical reactions. Initially, the drug acts by lowering a substance known as nitric oxide. This causes a relaxation of the arteries and allows blood to flow more easily. This also causes a drop in blood pressure, which makes it easier to achieve an erection.
It then works by slowing the action of phosphodiesterase type 5 in the fetus. This prevents the enzyme from degrading nitric oxide, which leads to increased blood flow and an erection.
In a first study, ex vivo human chorionic plate arterial rings were pre-constricted with U46619 and then treated with various concentrations of sildenafil citrate. These concentrations ranged from 10-8 M to 1 x 10-4 M. After treatment, the mean relaxation was greater in the sildenafil citrate groups compared to the control group.
This was found to be a dose dependent response, with the 50% relaxation elicited by the lowest concentration being about one-quarter of that of the highest concentration tested. These findings were replicated in series 2 and 3.
Using a randomized, double-blind, placebo-controlled two-way crossover design, patients with ED were administered a single oral 100-mg dose of either study drug or matching placebo. They underwent four assessments during treatment periods. Each assessment was performed 10 min after the start of study medication and lasted for 60 min.
The results showed that Fildena 150 decreased resting systolic and diastolic blood pressure by 7% and 10%, respectively, compared to baseline. This effect was similar to that seen with nitroglycerin. This resulted in a reduced risk of pulmonary artery occlusion (PAH) in the patients who took sildenafil.
It is important to note that sildenafil can cause severe side effects in people with liver or kidney disease or when co-administered with CYP3A4 inhibitors such as erythromycin or cimetidine. Therefore, it is not recommended to use it in these cases. Moreover, it should not be taken by people who are taking nitrates such as nitroglycerin or an alpha blocker.
Cyclic Guanosine Monophosphate
The cyclic guanosine monophosphate (cGMP) pathway is an important intracellular second messenger molecule that regulates a large range of biological processes, including vasodilation, retinal phototransduction, calcium homeostasis, and neurotransmission. cGMP is produced in response to membrane-impermeable peptide hormones, most notably nitric oxide (NO). Once synthesized, cGMP exerts its effects through a variety of downstream effector molecules, including cyclic guanosine monophosphate-dependent protein kinases, cGMP-gated cation channels, and phosphodiesterases.
The primary cellular target of cGMP is a cyclic guanosine monophosphate-dependent enzyme called guanylate cyclase (GC). Activation of GC leads to the production of cGMP, which acts as a signal to induce several cellular responses. These include the activation of intracellular protein kinases, activation of cGMP-gated cation channel conductance, glycogenolysis, and cellular apoptosis. In addition, cGMP has a relaxing effect on smooth muscle tissue. This relaxation also enhances blood flow and the movement of fluids through the vascular system.
During sexual stimulation, the nerve endings in the spongy erectile tissue release nitric oxide into the bloodstream. This nitric oxide activates the guanylate cyclase to convert guanosine triphosphate (GTP) into cGMP. The cGMP in the blood is then hydrolysed by PDE-5, which restores GTP to its inactive form.
PDE-5 inhibitors are used to treat conditions such as erectile dysfunction, benign prostatic hyperplasia, and high blood pressure. Sildenafil citrate is a member of this class of drugs that inhibits the activity of PDE-5 enzymes and promotes the normal function of the male reproductive system.
Fildena 120 are used to treat a variety of different medical conditions, and they come in tablet form that is usually taken orally. The dosage of these tablets can vary depending on the underlying condition and the patient's overall health.
A patient's dietary habits and lifestyle can also affect how well this drug works for them. The FDA has approved sildenafil citrate as a treatment for erectile dysfunction and high blood pressure, but it can be effective in treating other conditions as well.
The nitric oxide-soluble guanylate cyclase-cGMP signaling pathway is a major modulator of numerous physiological processes, such as blood flow, inflammation, and fibrosis. Small-molecule heme-dependent agonists of the sGC pathway, known as sGC stimulators, synergize with endogenous NO signaling to stimulate cGMP synthesis and provide therapeutic benefits in many diseases that impair cGMP production or NO release.
The PDE-5 inhibitors (sildenafil, tadalafil and vardenafil) are the standard medications for treating erectile dysfunction. These drugs work by blocking a chemical called phosphodiesterase-5, which is found in the walls of blood vessels.
In people with pulmonary hypertension, a form of high blood pressure in the lungs, PDE-5 inhibitors can help to increase blood flow to the lungs and lower blood pressure. They can also help to slow the progression of the condition and reverse some of the damage caused by PH.
PDE-5 inhibitors are usually taken as tablets or as a shot, but they can also be used as a topical ointment. The most common side effect of Fildena Super Active is a headache, but strategies to reduce this side effect include reducing the dosage or taking an over-the-counter (OTC) pain medication.
A small amount of research suggests that black ginger, or kaempferia parviflora, may have a slight inhibiting effect on the enzyme PDE5. However, more studies are needed to determine the safety and effectiveness of this herbal supplement.
Another plant, Eurycoma longifolia, also known as tongkat ali, contains PDE5 inhibitors but has not been shown to be effective in treating ED. This herb is found in a number of supplements and herbal remedies, but these should not be taken without the supervision of your doctor.
The FDA has warned that many herbal or natural remedies for ED may contain ingredients that are similar to those in prescription medications. Some of these ingredients can cause severe or life-threatening side effects.
Moreover, the ingredients in certain herbs and supplements may not be listed on their labels. They can also interact with other drugs, causing harmful side effects or even death.
For this reason, it’s important to talk to your doctor about any herbal or natural products that you use before beginning treatment with a PDE-5 inhibitor. It’s also best to consult with your doctor before starting a new treatment plan if you’re on medication for any other health condition.
Most of the side effects of Fildena Professional 100 Mg are mild and temporary, but a few serious ones can occur. These include priapism, which is a prolonged and painful type of penile erection that can damage the penis and cause hearing loss. This is a rare but serious side effect that can require immediate medical attention.
When a person is sexually aroused, the brain sends chemical messages to the nerves that supply blood to the penis. These messages cause the blood vessels of the penis to relax and open up, allowing blood to flow in and fill the spaces between the cells. This creates pressure in the corpora cavernosa (the space within the penis) that makes the penis expand and forms an erection.
When the muscles of the penis contract, the blood in the veins dries up and stops flowing into the erectile tissue. This prevents the body from getting an erection during the rigid phase of the erection process and also helps the erection to stay in place.
The erection is sustained by the tunica albuginea, which surrounds the corpora cavernosa and helps to trap blood in the erectile tissue. The tunica albuginea also limits venous drainage from the sinusoids and allows tumescence to occur in the penis.
Veno-occlusive disease, which affects the veins in the penis, can interfere with this process. It is a common condition that can lead to ED.
Some medications can also make it harder for the body to get an erection. These include blood thinners, antidepressants, and some ED medications.
Depending on your medical condition, the doctor may order certain tests to determine why you are having problems with your erections. These tests may include a nocturnal penile tumescence study, which determines how many times you have an erection while you sleep.
In some cases, the doctor will prescribe a pill to help you have an erection when you are sexually aroused. A drug called sildenafil citrate is a popular option, which works by increasing blood flow to your penis.
Fildena 200 is not a cure for ED, but it can help men who have trouble maintaining an erection to achieve orgasm and have satisfactory sex. It can also help reduce stress and anxiety that often contribute to ED.
The pill should be taken before going to bed, as it can take several hours for the drug to be absorbed into the bloodstream. It is important to talk to the doctor about any medications you are taking and about your sex habits so that the prescription can be tailored to your needs.