Sildenafil Citrate, which is Malegra’s chemical name, is another name for it. Malegra 200 ED medication works best when taken on an empty stomach and one hour prior to sexual activity. If erectile dysfunction is moderate, this medication lasts about 5.30 to 6 hours. Malegra prolongs erection duration by causing PDE5 to degrade cGMP. It is a very popular and highly effective treatment for ED impotence all around the world.